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Differential Gene Expression

Group 1:         Timepoint:        Sex:        Mouse Model:    
Group 2:    

−20240102030405060
WT_Pkd1 vs Pkd1_KO - Male, Week 7log(Fold Change)-log(p value)
Expression
Utrn
66.4
0.703
4.97e-2
Wasf1
4.56
0.326
9.85e-3
Hebp2
5.61
0.385
4.51e-3
Rtn4ip1
53.8
-0.207
5.54e-3
Sim1
15.6
-0.332
3.09e-2
Cdk1
6.06
1.94
4.7e-10
Cabcoco1
25.6
-0.445
7.11e-4
Tmpo
22.4
0.379
3.82e-5
Mtfr2
0.74
1.61
1.25e-3
Ntn4
16.9
-1.65
1.59e-15
Sirt1
11.4
-0.208
4.5e-2
Pbld2
14.9
-0.392
4.97e-2
Hkdc1
2.32
0.661
5.02e-3
Ppa1
49.3
0.201
9.93e-3
Sgpl1
35.1
0.306
1.6e-3
Cand1
39
-0.122
4.18e-2
Tbk1
28.8
-0.196
3.3e-2
E2f7
0.55
1.36
8.6e-3
Helb
14.3
-0.193
3.03e-2
Prmt2
23.2
0.384
2.92e-2
Septin8
21.3
0.472
4.35e-2
Dhx40
63.4
-0.202
1.26e-2
Slc13a3
168
-0.548
4.04e-2
Kcnab3
1.49
0.602
2e-3
Wnt9b
4.96
0.586
2.3e-2

Note: Positive Log(Fold Change) indicates up-regulation in Group1

Overview of TRAP RNA-seq study design


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Citation

When using this data, please cite the following reference.
Zhang, C., Rehman, M., Tian, X., Pei, S.L.C., Gu, J., Bell, T.A., Dong, K., Tham, M.S., Cai, Y., Wei, Z., et al. (2024). Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Nat. Commun. 15, 3698. 10.1038/s41467-024-48025-6.